| Ayurveda is a form of medicine that has been
practiced in India for thousands of years and comes from the root
words "Ayur" = life, and "Veda" = revealed knowledge. Certainly, the
phrase "revealed knowledge" is appropriate, because as the keen gaze
of scientists searching for new remedies is turned on these ancient
cures, intensive research is finding the evidence that explains
their success.
Some of the herbs from Ayurvedic tradition that
are beginning to come into their own universally are Gymnema
Sylvestre (blood sugar control), Boswellia Serrata and
Turmeric (inflammation)
Guggul Gum
- (cholesterol), Bacopa Monnieri (ADD/ADHD) ,
and Ashwaganda ( an adaptogen and antidepressant).
|
Turmeric (often referred to as Curcumin for the
active ingredient) has been used in folk medicine in India for
many thousands of years for indigestion, (especially flatulence and
dyspepsia) and as a topical application for skin outbreaks,
including chicken pox and infected wounds. It is, of course, one of
the major ingredients in curry powder, a staple of most Indian
cuisine, and this is an excellent example of form following function
in the use of a herb! While the actual chemical structure of
turmeric was determined in 1910, studies in the 70s concluded that
the active ingredients in turmeric, the phenolics and curcuminoids,
have unique importance as anti-inflammatories and antioxidants.
|
Their action as an anti inflammatory is achieved by inhibition of
the enzymes which enable the body to produce Arachidonic acid, thus
lessening the inflammatory effect. Its action is similar to that of
aspirin, but differs from aspirin in that it does not affect the
prevention of vascular thrombosis, which aspirin in large doses can
certainly do. This is an
important advantage for Turmeric (curcumin) over aspirin, since
curcumin selectively inhibits synthesis of inflammatory
prostaglandins but does not affect the synthesis of prostacyclin.
[1] Prostacyclin is an important factor in preventing vascular
thrombosis, and any drug that affects its synthesis, especially when
used in large doses, may increase the risk of this dangerous
condition. Curcumin may therefore be preferable for patients who are
prone to vascular thrombosis and require anti-inflammatory and/or
antiarthritic therapy.
Many tests have shown an improvement in ALL
participants - to my mind, a powerful endorsement - and the
antioxidant qualities are an added bonus.
Much exciting research has shown an important
role for Curcumin in Cancer prevention. I am indebted to
Catherine Cox, of the yahoo group
AdvancingBudwigProtocol
for this synopsis:
Here are a few of Curcumin's
"greatest hits".
First, in contrast to previous reports, curcumin
activates the JNK pathway. This is a death pathway
that is activated by most chemotherapy drugs. Now we
find that curcumin can induce these very same death
pathways.
http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15256484
Curcumin also activates the PPAR-gamma genetic
pathway. This pathway inhibits cancer growth in
many, many different ways. Interestingly, the
activation of this pathway inhibits the _expression
of the epidermal growth factor receptor. This is big
news. Remember the "fine living icon" Martha Stewart
and her little trip to Federal Prison? She lied
about her stock dealings with the CEO of
http://www.imclone.com
.
ImClone was attempting to get approval for a
monoclonal antibody that blocked the binding of
epidermal growth factor to its receptor. This
monoclonal antibody, Erbitux, has now been approved
for the treatment of certain kinds of cancers but
only when used with chemotherapy. If the information
cited above about curcumin and its ability to reduce
the synthesis of the epidermal growth factor
receptor is correct, the monoclonal antibody Erbitux
is irrelevant.
Curcumin also inhibits the tyrosine kinase activity
and _expression of the epidermal growth factor
receptor p185neu/c-erbb-2/Her2. The popular
monoclonal antibody inhibitor of this receptor is
called Herceptin and it is made by Genentech. Like
Erbitux, this product is now irrelevant if curcumin
can downregulate the _expression of this receptor.
http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=10430096
Most important, curcumin inhibits the activation of
NF-kappaB and AKT. NF-kappaB is a genetic factor
that activates the synthesis of pro-inflammatory
hormones and anti-cell death survival proteins. AKT
is an enzyme that activates other anti-death
pathways. It is critical that both these pathways be
inhibited if cancer cell death is to achieved. This
scientific paper, as yet to be published, is simply
excellent in its detail and analysis of curcumin
function.
http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16219905
The Janus kinase-Stat pathway is a MAJOR growth
pathway for leukemia cells. Curcumin blocks this
pathway at one fundamental level.
http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=14634121
The genetic factor Egr-1 is a major factor in many
biochemical pathways, including cancer and HIV.
Curcumin inhibits this pathway.
http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=10674404
The ability of curcumin to downregulate the
_expression of the epidermal growth factor receptor
is dependent on its ability to inhibit the Egr-1
pathway.
http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16170359
Finally, curcumin inhibits multi-drug resistance
normally induced by chemotherapy drugs.
http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16021489
http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15476675
http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12167476
http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15090070
A general review on the ability of curcumin to
inhibit the synthesis of anti-cell death molecules
in cancer cells.
http://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12807727
|
Gymnema Sylvestre
A Dr. K. Shanmugasundaram, professor at the medical school of the
University of Madras in India, conducted tests using Gymnema on
people who needed insulin shots daily. Previous tests on animals
whose beta cells were destroyed with a chemical called alloxan
showed, after a few months of supplementation with Gymnema, that it
either repairs or regenerates the beta cells. Insulin-dependent
humans have beta cells that don't produce insulin because of a
hereditary defect. The scientists assumed that if they could
generate beta cells in animals that produce insulin, they could do
it in humans, too. That's exactly what happened in the clinical
tests on humans. Their insulin requirement dropped, along with
lowered blood sugar and improved glucose utilization. Also, the
glycogen (stored blood sugar) in the liver became normal after five
and a half months of taking Gymnema. Dr. Shanmugasundaram concluded
in his clinical report that after administration of Gymnema for
several months, "insulin requirements go down."**
Boswellia Serrata - In
patients suffering from ulcerative colitis grade II and III the
effect of Boswellia serrata gum resin preparation (350 mg thrice
daily for 6 weeks) on stool properties, histolopathology and scan
microscopy of rectal biopsies, blood parameters including Hb, serum
iron, calcium, phosphorus, proteins, total leukocytes and
eosinophils was studied. Patients receiving sulfasalazine (1 g
thrice daily) served as controls. All parameters tested improved
after treatment with Boswellia serrata gum resin, the results being
similar compared to controls: 82% out of treated patients went into
remission; in case of sulfasalazine remission rate was 75%."
Eur J Med Res 1997
Jan;2(1):37-43)
Guggul
(which is actually Myrrh - maybe the Wise Men were really on to
something), lowers both cholesterol (Science 2002 May
31;296(5573):1703-6) and triglycerides (J
Assoc Physicians India. 1981 Jan;29(1):13-7. )
J Ethnopharmacol 2002 Jul;81(2):281-5)
Ashwaganda (Withania somnifera),
also known as Winter cherry, has been
used for thousands of years as a popular remedy for many conditions.
Perhaps its main use, as described in Ayurvedic literature, is as a
daily, long-term 'rasayana' or rejuvenating treatment. Ashwaganda is
one of the best known and best researched Ayurvedic herbs and holds
a place in the Ayurvedic traditions similar to Ginseng in Chinese
therapies. For that reason, Ashwagandha has been often referred to
as the 'Indian Ginseng'. It is one of the best health tonics and
restorative agents that have been used to treat general debility,
exhaustion, stress induced fatigue and insomnia. Studies have shown
its rejuvenating effect, particularly for the muscles and marrow.
Various alkaloids and withanoloides in Withania somnifera have shown
impressive results in scientific tests, two of them as stimulants
for the immune system.
Dr. Lise
Anschuler, who teaches at Bastyr University,
lists the following benefits:
-
Contains high levels of an
absorbable plant iron
-
Improves the results of cancer
treatment
-
Reduces the side effects
chemotherapy.
-
Increases Red Blood Cells
through its action on the bone marrow.
-
She personally finds it
effective for anxiety
-
It induces restful sleep.
-
It is an adaptogen, balancing
the body
-
It spares the release of
Cortisol, moderating its effects on such conditions as PMS,
depression, thyroid imbalances, & menstrual irregularities
-
Helpful for arthritis and all
chronic inflammatory conditions.
-
Excellent for older people in
a weakened state
-
Helps control rhinitis &
atopic dermatitis.
Garcinia Cambogia is
another "new" star: marketed as Citrimax and also known as
Hydroxycitric acid, its effect on appetite and weight loss has
been the subject of intense study and interest. The rind of this
fruit has been used in South East Asia as a digestive aid for many
centuries, but now we know that through inhibition of certain
enzymes it controls the glycogen/glucose cycle in our bodies,
diminishing appetite, reducing food intake, and suppressing fatty
acid synthesis.
Studies have shown that (-) hydroxycitric acid
(HCA) present in the Garcinia Cambogia extract (containing not less
than 50% w/w of HCA) is known to inhibit lipogenesis and fatty acid
synthesis. It acts by inhibiting the citrate cleavage enzyme which
catalyzes the formation of precursors for fatty acid synthesis. In a
study published in International Journal of Obesity (1996), HCA has
also been shown to boost basal metabolic rate so the body continues
to burn calories and lose weight.
Increasingly these names are being mentioned in the Press and on TV.
But while Ayurveda has certainly discovered and used many highly
effective substances. it has never really been about individual
remedies, but about something dear to my own heart, as my readers
well know: and that is: Balance. Ayurvedic formulas usually
contain a blend of herbs. Ayurveda believes that the normal
state for the body is a state of health, and that when disease
overcomes it, the body struggles to heal itself: the role of
medicine is to support the struggle and
return the body to natural
balance.
A Doctor skilled in the practice of Ayurvedic
medicine will not content himself with just suggesting a herbal
remedy for the problem that is presenting, but will determine the
characteristics of the patient and counsel on diet, exercise,
massage and meditation as well as prescribing the appropriate
substances. Ayurveda places everyone into one of three categories,
according to a series of criteria based on physical and mental clues
which determine their "Constitutional Type". While to a certain
extent the practice of Ayurved seems to be developing away from this
particular diagnostic method, it can still be of value in
determining what remedy to choose: certain constitutional types are
definitely more susceptible to certain ailments, and matching the
patterns of digestion, absorption and diet can be an important part
of the cure.
Whether one's interest in Ayurveda follows the
more traditional pattern, or whether one has simply benefited from
one of the individual stars in its healing firmament, this ancient
approach to health has much to offer.
1.Srivastava,
V., et al. (1986). "Effect of Curcumin on Platelet Aggregation and
Vascular Prostacyclin Synthesis," Arzneim. Forsch
2.
J Ethnopharmacol, 30:295-300, 1990
Antidiabetic effect of a leaf extract from Gymnema sylvestre in
non-insulin-dependent diabetes mellitus patients.
Baskaran K, Kizar Ahamath B, Radha Shanmugasundaram K,
Shanmugasundaram ER.
Department of Biochemistry, Postgraduate Institute of Basic Medical
Sciences Madras, India.
The effectiveness of GS4, an extract from the leaves of Gymnema
sylvestre, in controlling hyperglycaemia was investigated in 22 Type
2 diabetic patients on conventional oral anti-hyperglycaemic agents.
GS4 (400 mg/day) was administered for 18-20 months as a supplement
to the conventional oral drugs. During GS4 supplementation, the
patients showed a significant reduction in blood glucose,
glycosylated haemoglobin and glycosylated plasma proteins, and
conventional drug dosage could be decreased. Five of the 22 diabetic
patients were able to discontinue their conventional drug and
maintain their blood glucose homeostasis with GS4 alone. These data
suggest that the beta cells may be regenerated/repaired in Type 2
diabetic patients on GS4 supplementation. This is supported by the
appearance of raised insulin levels in the serum of patients after
GS4 supplementation.
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