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How endlessly
complex and fascinating is the heart, how
imbued with both physical and sentimental
importance. This majestic muscle, with its
energy cells and electrified fibers, pumps
in our chests day in and day out, ideally
without our giving it a second thought,
making all of the functions of the body
possible.
Unfortunately for some, this
function most of us take for granted is the
focus of their worry and concern: the
American Heart Association estimates that
59,700,000 Americans are suffering from some
type of cardiovascular disease (CVD.)
While there are some
hopeful signs overall as far as actual heart
attacks are concerned, unfortunately
Doctors are seeing an increase in problems
associated with heart weakness, such
conditions as cardiomyopathy and congestive
heart failure.
There is a good deal of
speculation about the reason for this. In
my opinion, one reason is that these heart
weaknesses are the chronic
manifestation of poor diet and lifestyle
choices, as opposed to the the acute
manifestation, which is an actual heart
attack. They should be addressed in three
ways:
-
by modifying lifestyle
factors such as diet,
exercise and stress
levels
-
by controlling blood
sugar levels
-
by the judicious use of
nutrients and herbs to
protect and support
heart function.
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Interesting research suggests that fasting
just one day a
month positively affects cardiovascular health, possibly
through reduced exposure to glucose. Researchers theorize that this one day
without food gives the organs time to rest and work more
efficiently.
Implementing a program of
this nature will not only lessen the chances
of heart problems, but increase the chances
of surviving an event.
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Let's
start with overall guidelines for a
healthy dietary, which are simply
expressed: fresh, unprocessed,
varied and moderate.
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A huge 2004
study of over 39,000 people in 40 countries
people made an incontrovertible connection
between high blood sugar and cardiovascular
disease. About half of the subjects were
men, averaging 63 years of age, and the
researchers determined that only one man in
three had normal glucose and insulin
levels. I in 5 had diabetes that had gone
undetected, and over 1 in 4 had pre-diabetic
readings. This emphasizes the importance
of
controlling blood sugar.
Alarmingly, in December
2006, the Mayo Clinic published a paper
pointing out that bad diets are causing more
children to show sign of metabolic syndrome,
which leads to the kinds of diseases
previously found only in adults. Dr.
Weinstock, the author of the study, is
quoted as saying “Unfortunately, as the
population becomes less active and more
obese, we're seeing a rise in this
constellation of risk factors for
cardiovascular disease. That's of great
concern because of the increased risk for
heart attack, stroke and diabetes, and we're
seeing this occur in younger and younger
individuals.”
Consider the results of Dr.
Dean Ornish's 1998 heart treatment regimen,
published in JAMA (1998;
280: 2001-7). To summarize: there
were 20 patients in the experimental group,
and 15 in the control.
-
The experimental group
ate a diet which was 10% vegetarian, did
moderate aerobic exercise, added stress
management, and stopped smoking.
Experimental patients reduced chest pain
by 91% at the end of one year, and 72%
after 5 years
-
The control group
followed their individual Doctors'
recommendations, followed the American
Heart Association's Step 2 diet, and 60%
of them took lipid lowering drugs.
The control group reported an 186%
INCREASE in angina frequency after one
year, and a 36% increase after 5 years.
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Low density lipoproteins were
the same in both groups whether
they took or did not take lipid
lowering drugs. |
In the experimental group,
coronary artery blockage decreased by
3.1%, in the controls it increased by
11.86% The control group also experienced
twice as many cardiac events as the
experimental group.
These were, in my opinion,
very low impact interventions, since no
supplements or vitamins were used, and even
so - look at the results!
- Generous amounts of
olive oil are allowed on my diet, while
saturated fats from animal sources and
trans fats are eliminated .
- This change needs to
be accompanied by consistent healthful
exercise, such as brisk walking.
- Protein should be
supplied liberally from plant sources,
such as beans, nuts and soy, with
poultry, eggs, fish and meat a few times
a week, and red meat a few times a
month.
- Remember: many of the
herbs and spices have health benefits -
consider cayenne, turmeric and parsley
as examples. Season your food with the
good ones.
- Cheese and
yogurt
may be consumed on a daily basis, but in
small amounts.
- Fruits and vegetables
should be consumed in variety on a daily
basis.
- Make sure a goodly
proportion of your food is raw, for the
enzymes provided
- Walnuts and almonds
are encouraged as snacks. I like almond
butter in celery sticks, and walnuts in
my yoghurt.
- A glass of wine per
day (moderation rules - see
RESOURCES
at right for alcohol and Dementia) is an
acceptable addition,
- but your main drink
should be pure water.
- Green tea is
encouraged. One cup of coffee a day is
accepted.
Consider increasing raw
foods in your diet to offset the damaging
effect of a diet that consists mostly of
cooked foods. Enzymes are the difference
between raw and cooked foods. Enzymes are
powerful biochemical catalysts. They speed
burning or building reactions in the body
according to need, but enzymes are destroyed
by temperatures as low as 105 degrees, the
equivalent of light steaming.
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The role of
supplements and anti-oxidants |
Of particular interest is an
analysis from the Erasmus University Medical
School in Rotterdam (Am.
J. of Clin. Nutr., Feb 99; 69(2):261-6)
where subjects were graded by antioxidant
intake, and it was found that those in the
top third of beta-carotene intake
from food (2.11 mg per day) had 55% the risk
of heart attack of those in the bottom third
(0.84 mg per day). However, when intake
from food and supplements was combined,
the risk dipped to 49%. If the person in
question was a smoker, the protection was
even greater - only 33% of the risk of heart
attack as former smokers with low
beta-carotene consumption! (Nutr.
Sc. News; July 99: 313).
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Of
all antioxidants, the most important
for heart health is Co-enzyme Q10.
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CoQ10 is naturally present
in our cells, where it is essential for
cellular respiration and energy production.
However, our supplies become depleted as we
age, and replacing them from food is
marginally practicable. As an example, it
would require two gallons of chopped spinach
daily to provide 30 mgs of CoQ10.
Not only do we have less
CoQ10 in our bodies as we age, but since it
is a potent antioxidant, under conditions of
oxidative stress - for example, pollution,
smoking - available supplies of CoQ10 are
used first to answer that need, and less of
it is therefore available to supply the
needs of the cell. This sequence of events,
where our body contains less of the nutrient
through the natural process of aging,
increasing demands for it in its antioxidant
role deplete our remaining supplies, and
therefore less of it is available for
essential energy production in the body's
cells, illustrates the vital role CoQ10
plays in heart disease.
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It is the energy produced in
the cells of our hearts that
literally determines the
efficiency of our heartbeat! |
I remember CoQ10 being
attacked in Dr. Gott's newspaper column
years ago, and would like to quote Dr.
Julian Whitaker's reply verbatim:
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Dear Dr. Gott,
At first I was
incredulous, then alarmed by
your comments on CoQ10.
I have been
practicing medicine in
California for twenty years, and
have been dispensing,
prescribing and recommending
CoQ10 daily for over a decade
...
CoQ10 is not a
"non traditional" treatment of
cardiomyopathy: it is the most
powerful treatment of
cardiomyopathy available. It
increases the survival rate of
cardiomyopathy patients tenfold
compared to the combined
therapies of ACE inhibitors,
diuretics and Lanoxin ...
For your
reader with cardiomyopathy, you
need to set the record straight
... to withhold this information
from her is unreasonable,
unethical and will facilitate
her demise and potentially that
of many others
signed, Dr.
J.W. |
Dr. Judy, of the
Southeastern Institute of Biomedical
Research in Bradenton, FL, has been
conducting research into CoQ10 for nearly
two decades. He reports that studies on
over 4200 people show that CoQ10 reduced
heart problems in those already suffering
from them, improved pumping and heart
contraction, and reduced heart volume in
almost 90% of those tested within between 24
and 90 days of starting to supplement them
with from 100 to 250 mg per day.
|
In another study of 240 people
with ischemic heart disease, 85%
of those taking from 30 to 600
mg of CoQ10 per day ( Lynn's
note - 600 is a VERY high dose!)
showed results with lessening of
resting angina and exercise
induced ischemia. Arrythmias
were also reduced by 50 to 100%. |
Research in 2005 shed more light on
how CoQ10 may help. Clay Semenkovich of the
Washington University School of Medicine in
St. Louis, Missouri does not accept the
cholesterol/heart disease connection, but
suggests that with age, the energy producing
mechanisms in the mitochondria of the cells
become less efficient. This allows highly
re-active oxygen species to leak into the
blood stream, causing damage to the walls of
the blood vessels.
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One
of the original clinical researchers
into CoQ10's role in cardiovascular
health Dr. Per Langsjoen of Tyler
TX, went so far as to speak of it as
the
"crucial factor in cellular
bioenergetics and free radical
quenching". |
Dr. Whitaker's book,
Guide to Natural Healing, gives a number
of other study examples and a search will
turn them up in the hundreds: this is a
much researched and highly effective
heart nutrient.
At this stage, I'm sure no
one will be surprised to learn that 100 mg
of CoQ10 is the first thing I would
supplement with if I had heart problems of
any kind. to include high blood pressure. A
minimum dose of CoQ10 would be 30 mg. It
appears to be even more effective if taken
in conjunction with Vitamin E, but should in
any event always be taken in conjunction
with a form of fatty acids for maximum
absorption. There are
CoQ 10 products on the market now that are
combined with the lipids necessary for best
absorption, and while they cost a little
more they are documented to deliver more
CoQ10 to the cells.
Obviously the production of
energy in the heart cell is the key to
cardiovascular health, hence the importance
of Co-enzyme Q10. Another nutrient of
evolving interest is Pyruvate, which
is critical to myocardial energy metabolism,
and which the body under certain conditions
converts to Co-enzyme A. Much of the
interest arises from the fact that the
presence of adequate Acetyl Co-enzyme A in
the cells means that energy for the heart is
converted preferentially through fatty acid
oxidation, rather than carbohydrates or
glucose.
Studies have concluded
generally by saying that unfortunately, it
is difficult to come up with a means of
utilizing Pyruvate because it is not able to
penetrate the cells when taken by mouth.
Some years ago, I came across a supplement
called
CoEnzyme A which has surmounted that
problem, and which claims to be vital for
production of cellular energy and proper
fatty acid metabolism. I have suggested it
for a long time for Stress related problems,
but now add a recommendation for its use
also where heart problems are a concern.
See
RESOURCES at right for study.
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One of the main reason we
experience atherosclerotic
deposits in our arteries is that
we are chronically depleted of
the vitamins, minerals and amino
acids needed to maintain
arterial integrity. |
Over time, as the deficiency
of these nutrients continues, the deposits
represent a desperate attempt at artery
repair by our bodies.
A diet low
in Vitamin C leads to the formation
of lesions in the walls of blood vessels,
causing the blood vessel to actually leak
blood. This prompts a repair molecule called
Lipoprotein (a) to apply Apo (a), which we
can think of as a kind of repair tape, to
the affected area. As the damage continues
to occur, however, the response stimulus
overreacts, and the resulting
overcompensation leads to atherosclerotic
deposits.
Imagine, as long ago as the
1940s, two groups of Doctors - the Canadian
cardiologist Paterson, and Trimmer & Lundy
in the U.S. - had already noted that 70 to
80% of their patients had very low plasma
levels of Vitamin C.
It is obvious that if the
walls of our blood vessels were able to
repel the threatened buildup there would be
fewer deposits of the lipo protein (a)
particles, and this is the role experts
attribute to Proline and Lysine.
Lysine is an
essential amino acid: that is to say, the
body is unable to manufacture it and we must
obtain our supplies from our diet. Those of
us susceptible to fever blisters may be
aware that they erupt when there is too
little lysine in relation to Arginine in our
diet, and therefore we know how easy it is
to be deficient in L-Lysine.
It is also known that
L-Lysine is essential for calcium
metabolism, and that calcium plays a role
in regulating many of the cellular,
biochemical and molecular functions that are
frequently abnormal in cardiovascular
disease.
Proline is classified
as a non-essential amino acid ( our body can
manufacture it) but it appears that under
high risk conditions for heart disease, the
body is unable to manufacture enough.
Lysine and Proline are important to this
process because they are natural
anti-adhesives, not only preventing
the deposit of further fat globules in the
blood vessel wall, but releasing all types
of deposits which ate already there such as
low density lipoproteins. The recommended
amount is generally 500 mgs of each per
day, and up to several grams per day
therapeutically.
New research on the amino
acid L-Arginine is also of interest
here, particularly to angina sufferers. It
appears (research by the Mayo Clinic's Dr.
A. Lerman, published in Circulation)
that L-Arginine acts on the lining of blood
vessels to relax the muscle wall, thereby
easing chest pain as well as inhibiting the
build-up of plaque. Another study in
Circulation (Feb
1998;97:363-8) showed that
intravenously administered Vitamin C, or 1
gm oral Vitamin C daily, led to increased
arterial dilation in patients with chronic
heart failure. The method of action
appeared to be inhibiting the oxidation of
nitrous oxide, leaving it available to
ensure healthy dilation of the blood
vessels.
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When
considering other reasons for the
new epidemic of heart problems, it
is alarming to realize the
connection between NSAIDS (
non-steroidal anti-inflammatory
drugs, such as ibuprofen) and heart
failure. |
Jack Challem, the well known
nutrition writer, reports (Lets
Live Aug 2000) that Australian
researchers show that nearly ONE FIFTH of
heart failures may be attributed to these
drugs, which are very widely used. In the
same interesting article, Mr. Challem traces
the connection between cardiomyopathy and
mutation of the Coxsackie's B virus. While
this virus is relatively harmless in its
causative role of sore throats and the like,
it appears that in the absence of sufficient
Vitamin E and/or selenium (both of
which are undersupplied in diets of
processed foods) it can mutate and attack
the heart.
New research implicates
inflammation generally in poor heart
health: Dr. Giles &
colleagues (Am J
Respir Crit Care Med 2000;162:1348-1354)
examined a study conducted from 1976 to 1992
on 8900 adults, and stated "What we found
was that people with an elevated white count
(WBC) were 40% more likely to die from
coronary heart disease after taking into
account a number of traditional risk
factors". See
RESOURCES at right for more info.
Alarming new research shows that
simply breathing the
air we live in is linked to
the development of heart disease through the
inflammatory process.
The study showed that patients with a WBC
count over 7.6 were at much higher risk of
dying from Coronary Heart Disease, even
after adjusting for other risk factors. The
new findings support a role for
inflammation as a causal
factor in the pathogenesis of CHD, the
authors say. "We really don't know whether
reducing white count will lower the risk,"
Dr. Giles added in an interview. "That's
where we need more studies."
|
It
seems that persistent inflammation
(triggered by viruses, bacteria and
even toxins) causes the formation of
a protein called FIBRIN, which is
implicated in blood clots. |
A Dr. Sumi,
in Japan, has recently made the discovery
that an enzyme in a food called NATTO,
from fermented soybeans, can block this
process, and actually resolve thrombi. It
also decreases the viscosity of the blood,
and of course, thicker blood means higher
blood pressure and more work for the heart.
It goes without saying that this cannot be
used by people with bleeding problems, and
only under the care of a health professional
if you are already on blood thinners.
The marker
of systemic inflammation, a body wide
problem which, it now apears, includes the
heart, is C-reactive protein, or C-RP. The
main source of this protein is the body's
fat cells, and it is currently considered by
many MDs to be an even more accurate
predictor of heart problems than
homocysteine or cholesterol.
|
At least, while
the establishment continues to
disseminate misinformation about
fiber and cancer,
it is acknowledging that
insoluble fiber
lowers C-RP. |
Research in the UK has connected high levels
of C-reactive protein specifically to
abdominal fat, with the inflammatory process
leading through insulin resistance to
diabetes, and on to cardiovascular disease.
Two
key passages from a 2003 editorial by
Russell Tracy of the Vermont College of
Medicine follow:
"First,
the data fit well with a growing
body of evidence implicating adipose tissue
in general, and visceral adiposity in
particular, as key regulators of
inflammation, coagulation, and fibrinolysis.
Adipose tissue secretes
proinflammatory cytokines and fibrinolytic
regulators such as plasminogen
activator inhibitor.
Along with many possible
roles in atherogenesis and atherosclerotic
progression, inflammatory
mediators can activate coagulation by
stimulating monocytes to express
tissue factor
(as can C-RP itself )
and by causing disregulation in
natural anticoagulation."
"They
suggested that the role of visceral
fat may be more complex than
suspected, because even people
who are not obviously overweight may still
have disproportionately too much
visceral fat, with the result of a
predisposition toward insulin
resistance and atherosclerotic disease,
possibly through inappropriate
cytokine secretion.
".
Full text here.
See also a study in
RESOURCES at right
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Vitamin E is a natural enemy of
C-RP, preferably Vitamin E
with Gamma Tocopherol and
Tocotrienols. |
Tocotrienols
may prevent arterial plaque build-up, and
therefore lessen inflammation. Since C-RP is
also to a certain extent manufactured in the
liver, some
liver support is recommended.
There is
another important association is between
fruits and vegetables and inflammation. A
2001 study
found that beta carotene levels were
universally low where C-RP readings were
high. Examples of important carotenes are
lutein and lycopene.
|
The importance of Omega 3s in heart
disease has been a subject of much
interest in recent years, as the
evidence mounted. |
The latest
edition of the PUFA newsletter (September
2003) has a number of studies on the
importance of the proper balance of fatty
acids in a number of conditions, but
relevant to the heart, this:
|
Overall, the authors estimate
that even allowing for eating
lean fish and possible
confounders, eating fatty fish
was associated with a 34%
decrease in CHD mortality across
the 3 European countries.
(Am. J. of Epidemiology, 2000;
151:999-1006) |
I am sure
that one of the main methods of operation is
going to be the positive influence of Omega
3s on the anti-inflammatory cascade! Another
connection will be the effect of proper
balance of dietary fats on visceral adipose
tissue.
|
A warning,
however, for anyone who has an
implanted cardioverter
defibrillator (ICD) - Fish Oil
may do you harm, rather than
good.
A recent study
concluded that with this
particular class of heart
patients suffering from
ventricular tachycardia (VT) or
ventricular fibrillation (VF),
there was no benefit and some
risk. The researchers
emphasized that their study does
not negate other studies which
show benefit for Fish Oil and
Omega 3 use in other heart
conditions.
Journal of the
American Medical Association
(vol 293, pp2884-2891), June
2005 |
Inflammation may be one of the connections
to the fact that high levels of
iron are a risk
for heart disease: although iron is an
essential and important nutrient, excessive
levels can be very dangerous for the liver
and the heart, and can cause significant
harm.
|
A new
study has shown that excess iron can
cause damage to the endothelium, the
inner lining of blood vessels,
causing inflammation and increasing
a person's chances of developing
hardening of the arteries and heart
attack. |
The
mechanism of action seems to be that high
iron levels impede the action of nitric
oxide, a chemical released by the
endothelium which aids on keeping blood
vessels relaxed. The lead study
investigator, Dr. Hidehiro Matsuoka of
Kurume Medical Scholl, states that consuming
high amounts of iron long term may increase
iron levels in the body, and suggests that
people over 40 who have other risk factors
for heart disease might find it useful to
have their iron levels checked.
Researchers
in his study injected volunteers with high
doses of iron (0.7 mgs per kg of body
weight) and used ultrasound imagery to
observe the functioning of the artery
walls: they found that the iron raised
levels of malondialdehyde, a chemical marker
for oxidation, and inhibited normal
endothelial function.
|
A
caveat: older women need to
watch their iron levels: poor
absorption as we age can cause them
to be dangerously low. The answer
is to have the situation checked by
a blood test before taking or not
taking iron supplements!! |
As if the
damage to the heart were not bad enough, a
study from the American Academy of Neurology
(June 2003) links hemochromatosis (fancy
word for high iron) to Parkinson's disease.
See RESOURCES
for more information.
There are
natural substances that can help
control iron levels: first among
them is IP6, a phytate from
rice that binds to iron and carries it out
of the body. The other one I recommend
highly is Lactoferrin. This is a
natural protein fraction extracted from
cow's milk, which affects iron in two ways:
.
it can enhance iron absorption by
assisting in its transport, leaving less
free iron in the blood .
.
by transporting the iron
to receptor cells in the intestine, it
also facilitates its elimination from
the body.
Interestingly, with the debunking of the HRT/Women's
heart health theory, which was based on the
possibility that extraordinarily low rate
of heart disease in young women was due to
hormonal protection, another theory which
makes more sense to me comes to the fore:
and that is that the blood-letting of the
menstrual cycle each month keeps IRON
levels low in pre-menopausal women. For a
complete report on this, see
RESOURCES at
right.
|
Meeting of the American Heart
Association's Council for High Blood
Pressure Research, Oct. 2000. I
am indebted to Dr. Mercola for this
information:
his newsletter is at
www.mercola.com |
I am
struck by the fact that each time I
address a substance I consider essential
for the heart I find myself saying to myself
as I write "THIS is the most important
one!" Maybe this is why I had a lady ask me
the other day whether I take all the things
I write about - well, the answer to that, of
course, is that I don't suffer from all the
things I write about! However, I do take a
considerable number of supplements, and
magnesium is high on my list of musts.
One because I did at one point
have a mild arrhythmia, two
because of its extreme importance in our
bodies and three because of
the high incidence of magnesium deficiency.
I would also add four many
people lack the stomach acid to absorb
magnesium.
To take
the second point, magnesium plays a part
in all the enzyme reactions in the body, and
also is essential ( with the other important
electrolyte, potassium) for the "firing" of
nerves and muscles. This means that few of
the body's vital processes take place
efficiently in the presence of low levels of
magnesium.
Third and
fourth points: among older people,
deficiencies of magnesium are especially
common because processed foods contain low
levels of the mineral, though it is abundant
in whole foods. Magnesium levels are also
adversely affected by alcohol consumption,
diuretics, antibiotics, diabetes, kidney
problems, and HRT. (Among younger women,
birth control has the same effect. Think
cramps!) Then too, production of
hydrochloric acid, necessary for absorption
of magnesium, decreases with age. Often
these deficiencies go unrecognized, because
magnesium levels are inefficiently measured
through blood tests: most magnesium is
stored in the cells. Ironic, that diuretics,
often prescribed for heart patients, deplete
the body not only of potassium ( a fact
which is often addressed) but also the
heart-important magnesium .
One of my
preferred reference books is Dr. Werbach's
Nutritional Influences on Illness,
and I looked in the index to refresh my
memory on some of the uses of magnesium: it
did not surprise me to find some 47 health
conditions listed with the relevant
research, since some naturopathic health
professionals consider
|
asthma, heart problems,
fibromyalgia, menopause, PMS and
migraine, most kidney stones, and
some cardiac problems |
all to be,
in one degree or another, magnesium
deficiency diseases.
The role
of magnesium in cardiac arrythmias was
first acknowledged as long ago as 1945, and
in 1989 the American Journal of
Cardiology
(63(14):43G-46G)
published a study by Dr. Roden saying "the
association between hypo-magnesia (Lynn:
hypo= low) and arrythmias ... has long been
recognized. More recently, acute
intervention with magnesium in patients who
are not hypomagnesic has demonstrated
arrhythmia suppression.."
In cases of
High Blood Pressure, a 1981 study found that
50% of patients with HBP had low magnesium
levels and their hypertension was reversed
when their magnesium levels rose. It is also
interesting that many women who develop HBP
do so after menopause, which makes the
magnesium connection particularly important
for them, especially if they are on HRT. As
a bonus, Dr. Alan Gaby (NSN
Vol.5 #9 p.402) says
adequate levels of magnesium in
post-menopausal women increase bone density
levels.
Another
really interesting study showed that when a
patient is deficient in magnesium, normal
levels of a medication which would usually
take care of the problem are of no help -
more is needed to get results, unless the
mineral deficiency is addressed.
|
Let me restate
that in reverse
if an underlying magnesium
deficiency is identified and
addressed, you may need less of
your medication to get results.
If such a deficiency exists and
is NOT addressed, you will need
higher than normal levels of
medication to get results. |
Magnesium
is also important for patients with
Cardiomyopathy, and Dr. Michael Murray
reports that magnesium levels "correlate
directly with survival rates". It is
unfortunate that many of the conventional
medical drugs used for these conditions,
such as calcium channel blockers, diuretics
and beta blockers, deplete the body of
magnesium.
Mentioning
Calcium Channel Blockers brings me to some
excellent information in Dr. Ronald
Hoffman's book, Intelligent Medicine,
(Simon & Schuster
1997, p.318-319) where
he points out that the method of action of
this class of drugs is to block the
spasm-inducing effect of calcium, thus
keeping blood vessels dilated. He points
out that calcium and magnesium compete
for the same receptor sites in the
smooth muscle wall of the blood vessel:
magnesium is the nutrient that relaxes
spasms, so its presence in greater amounts
than calcium will prevent spasms in the same
way calcium channel blockers do. This is
why, when my Doctor prescribed a calcium
blocker, I went away and took lots of
magnesium. Dr. H. says his protocol in
patients with advanced heart conditions is
to recommend magnesium in reverse ratio to
calcium. i.e., twice as much magnesium as
calcium. Buy his book, do: it is full of
excellent information. I recommend
magnesium bound to either aspartate or
citrate as being the most effective for
absorption, and also to avoid the
possibility of diarrhea that sometimes
accompanies high doses. I have had a hard
time up until now finding a means to get
extra magnesium in meaningful amounts at an
affordable price, but there are now some
powdered magnesiums on the market, and I can
recommend both Ionic Fizz Magnesium
and Magna-Calm as an excellent
strategy. I have also found a softgel
Magnesium 500 mg.
The following
information may be of interest to you:
|
Magnesium:
Research Misconduct?
For the past 15 years evidence
has stacked up showing patients
with acute coronary thrombosis
improve their survival chances
by 50 - 82.5% when given
intravenous magnesium of 32-66
mmol in the first 24 hours. The
single negative study showing
that magnesium had a worsening
effect on survival employed a
far higher dose of magnesium (80
mmol) than the other studies. (European
Heart J, 1991;12:12158),
and one other study showing no
benefit with magnesium employed
the low dose of 10 mmol in the
first 24 hours.
Although it would appear clear
to any first year medical
student that magnesium worked
well for coronary thrombosis
within the optimal dosage level
of 30 - 70 mmol; that 10 mmol
was shown to be too little, and
80 mmol had been shown to be too
much, in 1990/91, the Fourth
International Study on Infarct
Survival decided to do a major
study which was to definitely
determine whether magnesium was
beneficial when used for this
purpose. Although their own
meta-analysis of all earlier
studies showed that magnesium
was beneficial, the ISIS4
investigators also decided to
test magnesium against the drug
Catopril and a coronary
vasodilator.
Astonishingly, the ISIS
investigators chose to use the
80 mmol dosage for their study,
the one dosage that had
been found to be harmful.
It should be noted that the
ISIS4 study was funded to the
tune of almost $10 million by
Bristol Myers Squibb, the
manufacturers of Catopril. Not
surprisingly, magnesium lagged
behind the drugs.
As a result of this paper, many
hospitals ceased using magnesium
in their treatment of acute
coronary thrombosis.
The scandalous decision to use
an overdosage of magnesium in
this study must have caused the
loss of several thousand lives
within the study and many other
lives in other hospitals that
have now stopped using
magnesium. Both nutritional
pioneer Dr. Stephen Davies and
Dr. Damien Downing, editor of
the Journal of Nutritional
and Environmental Medicine,
criticized the designers of the
study for clearly selecting too
large a dose of intravenous
magnesium, and also for giving
magnesium too late and then too
quickly. Downing even titled
his editorial "Is ISIS4 research
misconduct?" (J
Nutr Environ Med, 1999;9:513)
Now comes Feb 13th 2002, when
Dr. Jeffrey L. Saver of the UCLA
Stroke Center told attendees of
the American Stroke
Association's 27th International
Stroke Conference that using
magnesium intravenously by
paramedics transporting acute
stroke victims to the hospital
resulted in "dramatic" recovery
rates and levels for 25% of the
patients. No side effects were
reported at all from a dose of 4
gms given en route, and 16 gms
more infused over the following
24 hours. Dr. Saver noted that
he instituted the study because
of the neuroprotective effect
noted for Magnesium in animals.
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Another important nutrient on the heart
health front is L-Carnitine.
I have been recommending it for many
years now, but we live in exciting times
nutritionally, and new research is
continually being published that underscores
its vital part in the cardiovascular system,
and for other health conditions. In fact, it
is a little hard to limit an article on
l-Carnitine JUST to the heart, because this
substance has been positively linked to
improvements in health problems as far
removed as obesity and Parkinsonism.
First, however, what it
is. The prefix "L" would lead one to suppose
that it is an amino acid - but strictly
speaking, although its structure is similar
to amino acids , it is more closely related
to the B vitamins. It is considered a
nonessential nutrient in the sense that the
body can manufacture it from other nutrients
present in the body (Lysine, Methionine, B6
among others, with Vitamin C being a
limiting factor), but it is highly essential
in its actions! In the diet it is found
mostly in muscle meats ( as the name would
suggest, coming from the Latin root for
meat), and while it is rare for an actual
clinical deficiency to exist, sub-optimal
levels can lead to many problems associated
with diabetes, obesity, cardiovascular
disease and possibly Alzheimer's and
muscular dystrophy. It is also being studied
for its role in energy with cancer patients.
The reason L-Carnitine
can be involved in such a wide range of
problems, and the reason for its extreme
importance in the maintenance of heart
health, is its influence on the destiny of
the massive amounts of carbohydrates in the
average American diet. Excess carbohydrates
are stored as fat, and Carnitine facilitates
the burning of fat for energy by making it
possible for the long chain fatty acids it
transports to enter the cell . After all, if
the fatty acids cannot reach the
mitochondria where they are transformed to
cellular energy, it stands to reason they
are going to be deposited in places where
the body will suffer from their presence, as
happens in fatty liver disease, fatty
build-up in the heart, and your plain old
everyday variety obesity, where fatty
build-up occurs in the muscles..
My hero Dr. Whitaker
compares the heart deficient in
Carnitine to a car without a fuel pump!
However, as you can plainly see, the heart
is not the only organ that can benefit from
more efficient burning of fats for energy:
Carnitine has its uses in the following
conditions: angina, myocardial infarction,
recovery from heart surgery, hypertension
and high cholesterol levels, also high
triglycerides, Alzheimer's, liver disease
(including alcohol induced liver problems)
diabetes, diabetic neuropathy male
infertility, diabetic neuropathy,
Parkinson's and many other more obscure
afflictions.
The average amount of
Carnitine found in the daily diet is app. 50
mgs: therapeutic levels range from 500 to
1000 mgs. deficiencies may be due to a
genetic error in Carnitine synthesis, or to
low levels of lysine or vitamin C, high
levels of homocysteine, or vegetarianism .
There do not appear to be any side effects
from its use even at high dosages, but it is
wise to increase Vitamin C supplementation,
since some studies show that high amounts of
Carnitine cause loss of Vitamin C from the
body.
As
science advances,
new forms of
L-Carnitine are
becoming available.
We now have
Carnitine bound to
Arginine, with
perhaps a greater
affinity for brain
energy, and an
exciting new
compound called
Ester Carnitine,
which is Propionyl L
Carnitine bound to
Glycine.
A 2001
study in
Cardiovascular
research
by study
by Lango
et al
said
"It has
also
been
shown
that
propionyl-L-carnitine,
which
penetrates
faster
than
carnitine
into
myocytes,
is
effective
in
inhibiting
production
of free
radicals.
Beneficial
effects
of
carnitine
supplementation
have
been
demonstrated
under a
variety
of
clinical
conditions
such as
acute
cardiac
ischemia,
during
extracorporeal
circulation,
in
carnitine-dependent
cardiomyopathy
as well
as in
patients
with
chronic
circulatory
failure
and in
cardiogenic
shock."
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Carnitine is also
sometimes marketed as DL-Carnitine, which in
my opinion should be avoided since some
experts say it interferes with the body's
use of natural L-Carnitine.
Athletes have known about
Carnitine's ability to burn fat for energy
for some time, but heart disease sufferers
are just beginning to realize the benefits
that come from using a substance that
provides the heart with its main fuel: the
heart gets two thirds of its energy from
burning fat! Less pain and more endurance
can be associated with supplementing with
L-Carnitine, with no downside! It works
synergistically with Coenzyme Q 10.
- Prime among other
nutrients is Vitamin E. Whenever
Vitamin E is mentioned, i still feel a
deep sorrow as I reflect on the way the
two Doctors Shute, who first asserted
that Vitamin E was helpful in
cardiovascular disease, were treated.
Sneered at and discredited by their
peers, I wish they were alive today to
see how thoroughly they have been
vindicated - find me a Doctor who
doesn't take Vitamin E himself! They
probably would never have dreamed that
these words would pass my pen (mouse),
but I think the role of vitamin E in
heart disease is well enough known now
to need to comment from me. I will say
that in my opinion not only is Vitamin E
important when you have heart disease,
but taking it regularly when you are
healthy can play a role in averting it.
I suggest a minimum of 400 i.u. of
natural d-alpha tocopherol per day, and
for maximum effect, look for a formula
which contains the
tocotrienols
as well.
- Other nutritional
substances I recommend are: a balance of
Essential Fatty Acids, to protect
the cells of the heart. For serious
heart problems, I suggest adding one
gram of
Fish Liver Oil.
Of interest here is a report by Dr.
Roberto Marchioli of Milan, Italy,
announcing to the American College of
Cardiology in New Orleans LA in April of
1999, that a study of 12,000 patients
with heart disease had found that those
patients using the FLO had a 29% lower
risk of dying. See
RESOURCES at right for another
new study.
- Avoid trans fatty
acids - a diet rich in foods
containing trans fatty acids increases
concentrations of LDL cholesterol.
However, unlike saturated fats, trans
fatty acids also decrease
concentrations of HDL cholesterol, which
appears to significantly impair
endothelial function, Dutch researchers
report.
"By measuring arterial vasodilation, we
compared the effects of trans fatty
acids with those of saturated fatty
acids to determine whether the decrease
in HDL cholesterol posed an additional
risk of cardiovascular disease," Dr.
Nicole M. de Roos, from Wageningen
University, told Reuters Health.
In a randomized crossover trial, Dr. de
Roos and colleagues put 29 healthy
subjects on two controlled diets,
according to their report in the July
issue of Atherosclerosis, Thrombosis and
Vascular Biology . The subjects consumed
each diet, for 4 weeks. Both diets
contained 9.2 energy percent from either
trans fatty acids (Trans-diet) or
saturated fatty acids (Sat-diet).
Dr. de Roos' group found that when
subjects consumed trans fats instead of
saturated fatty acids HDL-cholesterol
levels went down by about 26% and
arterial dilation was impaired by about
one third. "When patients consumed a
diet containing saturated fats,
vasodilation was about 6.5% of baseline
diameter, while it was about 4% of
baseline diameter on the diet rich in
trans fats," Dr. de Roos said.
Given their findings, Dr. de Roos
believes that "we should try to ban
trans fatty acids from our diets and
replace them with natural oils,
before they are hydrogenated, or by
tropical saturated fats that are
rich in C14, C16 fatty acids, which do
not lower HDL cholesterol." By
tropical, he means Palm Oil and/or
Coconut Oil, which both have very
interesting benefits. See
RESOURCES
at right
Arterioscler Thromb Vasc Biol
2001;21:00-00.
- I also recommend a
good trace mineral combination,
necessary for the regulation of the
heart rhythm (Balch) and selenium
in more than trace amounts - 100 to 200
mcgs. There is some research which
implicates a deficiency of this mineral
in heart problems.
- I considered putting
Pycnogenol, or
OPCs under herbs, since they
are plant based but I will list them
here. along with Resveratrol.
These are potent antioxidants, and have
a beneficial effect on
micro-circulation, possibly because
they strengthen as well as protect the
cell. They are also anti-inflammatory in
nature - see
RESOURCES at right for more
information.
- An article by Dr.
Anthony Cichoke (Health Products Mar
1999 p.22) cites research showing that
proteolytic enzymes (those which
break down protein) can: improve
circulation, help fight plaque build-up
on blood vessel walls, decrease LDL and
triglyceride levels, and maintain proper
equilibrium between blood clotting and
the break-up of blood clots. He says
that proteolytic enzymes help in 5
ways: they are a natural inhibitor
of inflammation which can occur in
the blood vessels, they aid the
efficiency of blood flow, they decrease
pain and edema, they increase
circulation and thereby improve the
supply of nutrients to the tissues, they
dissolve micro thrombi and inhibit clot
formation. In support of Dr. Cichoke, a
recent study in the New England
Journal of Medicine (Ricker
et al,2000;342(12):836-843)
followed over 28,000 women after
menopause to find out what the most
common predictor of heart disease would
be. The researchers were looking at 12
markers, and of them all, inflammation
turned out to be the most accurate
fore-runner of cardiovascular accidents.
Here is a list of some of
the herbs that are protective of the heart
-
-
Garlic
- this looms above all others on the
list in importance, because it has so
many well-documented effects, not only
on the heart and circulation, but on
general well-being. It is a giant in
the health field, and one I think
everyone can benefit from using!
- Hawthorn Berry
- its effects on the heart are as
important as garlic, but it has a more
narrow application. Be careful with
Hawthorn berry if you are using Digoxin
or Lanoxin: consult an expert.
- Cayenne - for
its effect on circulation.
-
Ginger - for its
anti-inflammatory properties, and as a
digestive aid. See
RESOURCES
at right for more about this amazing
herb.
- Motherwort -
one of my personal favorites with a
record of use going back to the Middle
Ages - it is particularly useful for
palpitations where stress is a factor.
- Butchers Broom
- Ginkgo Biloba
- Bilberry
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There are many
combinations which include some
or all of these herbs. Do be
very aware that if you are
taking prescription medications
and have serious problems,
certain of these herbs can have
potentially serious effects.
You REALLY need to do two
things: make sure your Medical
Doctor knows what you are doing,
and do it in conjunction with a
natural health professional who
can work with your Doctor for
the best results. |
I hope this
series has been helpful to those who are
addressing heart problems, and to those who
want to avoid them. I would like to
emphasize again that none of these things
are going to be helpful unless you first
address your diet, introducing more
fresh and unprocessed foods, fruits and
vegetables, fish, olive oil, garlic,
walnuts, and herbs into your cooking, and
make a commitment to a regular exercise
program that is right for you.
Dr. Weiss's book is an excellent overall
guide for regaining heart health!
There is no
doubt that the pendulum is finally swinging
back from the point where people simply
surrendered their health into the hands of
others, and moving back to the point where
we will realize that much of what happens to
our bodies is our own responsibility: we
need to remember that we are flesh and
blood, of the animal world: the principles
we never abandoned for our beloved pets and
prize livestock apply just as much to us: we
have to have the proper nutrition and we
have to stay active, otherwise we pay the
price. My aim is to be your guide along the
path - I hope to provide helpful insights in
the search for Good Health!
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