Tell your
friends about Vitamin Lady and watch the Product Credits in roll in!
Stress Cancer, vitamins, supplements, minerals and herbs online health store
The persistent activation of the
hypothalamic-pituitary-adrenal axis and the sympathetic-adrenal-medullary axes
in chronic stress response and in depression impairs the immune response and contributes
to the development and progression of some types of cancer.
This overview presents results from experimental animal
models, human studies, and clinical evidence that various cellular and molecular
immunological parameters are compromised in chronic stress and depression.
At the cellular level, stressed and depressed patients had
overall leukocytosis, high concentrations of circulating neutrophils, reduced
mitogen-stimulated lymphocyte proliferation and neutrophil phagocytosis.
At the molecular level, high levels of serum basal cortisol,
acute phase proteins, specific antibodies against herpes simplex virus type 1
and Epstein Barr virus, plasma concentration of interleukins IL-1, IL-6, and TNF-a,
and a shift in the balance of Th1 and Th2 immune response were observed. Both
stress and depression were associated with the decreased cytotoxic T-cell and
natural killer cell activities affecting the processes of the immune
surveillance of tumours, and the events that modulate the development and the
accumulation of somatic mutations and genomic instability.
DNA damage, growth and angiogenic factors, proteases, matrix
metalloproteinases, and reactive oxygen species were also related to the chronic
stress response and depression.
Behavioural strategies, psychological, and
psychopharmacotherapeutic interventions that enhance effective coping and reduce
affective distress showed beneficial effects in cancer patients.
A better understanding of the bidirectional communication
between the neuroendocrine and immune systems could contribute to novel clinical
and treatment strategies in oncology.
Lynn: my emphases
International
review of Psychiatry (http://taylorandfrancis.metapress.com/(1d5zfi45tecxxh55s14n5pii)/app/home/contribution.asp?referrer=parent&backto=issue,10,10;journal,4,37;linkingpublicationresults,1:100633,1)
*Product is shipping with 24 business hours on all in stock product. Back
ordered items generally ship with 5 to 7 business days. If your order will
not be shipped for longer than 10 business days, we will notify you by email.
**See our
Shipping Policy for
heavy items.
Prices subject to change without notice.
